Iowa State coach Matt Campbell says the bye week helped the injury sutuation, especially at running back.
Jirehl Brock and Cartevious Norton have battled injuries though the first half of the season.
If they are healthy it should boost a running game that has struggled in Big 12 play.
The Cyclones are 3-4 and are winless in the Big-12 after a string of close losses.
The Cyclones host Oklahoma on Saturday and need three wins to finish the season to earn a sixth straight bowl trip.